| 1 | GPT-6 Astra GPT-6 | OpenAI | +20.60 | 0.00 | 20.60 | 12 | 27 Oct 2026 |
| 2 | OpenAI Internal Research System — 2026-09 GPT-6 · internal / unreleased | OpenAI | +18.56 | 0.00 | 18.56 | 3 | 6 Oct 2026 |
| 3 | ChatGPT GPT | OpenAI | +18.93 | −1.68 | 17.26 | 7 | 4 Oct 2026 |
| 4 | AlphaFold 3 AlphaFold | Google DeepMind | +10.77 | 0.00 | 10.77 | 1 | 8 May 2024 |
| 5 | RFdiffusion RoseTTAFold | University of Washington Institute for Protein Design | +8.45 | 0.00 | 8.45 | 1 | 11 Jul 2023 |
| 6 | OpenAI Internal Research System — 2026-05 GPT-6 · internal / unreleased | OpenAI | +6.12 | 0.00 | 6.12 | 1 | 20 May 2026 |
| 7 | Anthropic Internal Research Model — 2026-08 Claude · internal / unreleased | Anthropic | +5.06 | 0.00 | 5.06 | 1 | 10 Aug 2026 |
| 8 | Gemini 3.1 Pro Gemini | Google DeepMind | +4.13 | 0.00 | 4.13 | 1 | 21 May 2026 |
| 9 | OpenAI Internal Research System — October 2026 Scientific Results OpenAI Internal Research · internal / unreleased | OpenAI | +3.98 | 0.00 | 3.98 | 1 | 26 Oct 2026 |
| 10 | AIFS AIFS | European Centre for Medium-Range Weather Forecasts | +3.68 | 0.00 | 3.68 | 1 | 25 Feb 2025 |
| 11 | PaLM 2 PaLM | Google DeepMind | +3.54 | 0.00 | 3.54 | 1 | 14 Dec 2023 |
| 12 | AlphaGenome AlphaGenome | Google DeepMind | +3.27 | 0.00 | 3.27 | 2 | 8 Sep 2026 |
| 13 | AlphaMissense AlphaFold | Google DeepMind | +2.65 | 0.00 | 2.65 | 1 | 19 Sep 2023 |
| 14 | GraphCast GraphCast | Google DeepMind | +2.65 | 0.00 | 2.65 | 1 | 14 Nov 2023 |
| 15 | OpenAI Codex Codex | OpenAI | +2.49 | −0.02 | 2.47 | 9 | 27 Oct 2026 |
| 16 | GenCast GraphCast | Google DeepMind | +2.46 | 0.00 | 2.46 | 1 | 4 Dec 2024 |
| 17 | WeatherNext Cyclones GraphCast | Google DeepMind | +2.43 | 0.00 | 2.43 | 1 | 6 Aug 2026 |
| 18 | GNoME GNoME | Google DeepMind | +2.38 | 0.00 | 2.38 | 2 | 29 Nov 2023 |
| 19 | AlphaChip AlphaChip | Google DeepMind | +2.31 | 0.00 | 2.31 | 1 | 9 Jun 2021 |
| 20 | Waymo Driver Waymo Driver | Waymo | +2.16 | 0.00 | 2.16 | 1 | 20 Dec 2023 |
| 21 | ESM3 ESM | EvolutionaryScale | +2.10 | 0.00 | 2.10 | 2 | 21 Sep 2026 |
| 22 | Google Flood Forecasting Model NeuralHydrology | Google | +2.00 | 0.00 | 2.00 | 1 | 20 Mar 2024 |
| 23 | RoseTTAFold All-Atom RoseTTAFold | University of Washington Institute for Protein Design | +1.94 | 0.00 | 1.94 | 1 | 7 Mar 2024 |
| 24 | MatterGen MatterGen | Microsoft | +1.74 | 0.00 | 1.74 | 1 | 15 Jan 2025 |
| 25 | Pangu-Weather Pangu | Huawei | +1.73 | 0.00 | 1.73 | 1 | 5 Jul 2023 |
| 26 | Evo Evo | Arc Institute | +1.67 | 0.00 | 1.67 | 1 | 14 Nov 2024 |
| 27 | Profluent Protein Language Model Profluent PLM | Profluent | +1.67 | 0.00 | 1.67 | 1 | 30 Jul 2025 |
| 28 | Aurora Aurora | Microsoft | +1.64 | 0.00 | 1.64 | 1 | 21 May 2025 |
| 29 | NeuralGCM NeuralGCM | Google DeepMind | +1.56 | 0.00 | 1.56 | 1 | 22 Jul 2024 |
| 30 | Claude 3.7 Sonnet Claude | Anthropic | +1.39 | −0.02 | 1.37 | 5 | 26 Oct 2026 |
| 31 | AlphaProteo AlphaProteo | Google DeepMind | +1.22 | 0.00 | 1.22 | 1 | 5 Sep 2024 |
| 32 | Anthropic Claude Science Internal Research Model — Scorpion Binder Campaign (2026) Claude · internal / unreleased | Anthropic | +1.22 | 0.00 | 1.22 | 1 | 20 Oct 2026 |
| 33 | codex-1 Codex | OpenAI | +1.16 | 0.00 | 1.16 | 2 | 8 Sep 2026 |
| 34 | Gemini Gemini | Google DeepMind | +1.13 | 0.00 | 1.13 | 1 | 14 May 2025 |
| 35 | Claude Fable 5 Claude | Anthropic | +1.12 | 0.00 | 1.12 | 4 | 31 Aug 2026 |
| 36 | GPT-5 Pro GPT | OpenAI | +1.01 | 0.00 | 1.01 | 1 | 24 Oct 2025 |
| 37 | AlphaDev AlphaZero | Google DeepMind | +0.96 | 0.00 | 0.96 | 1 | 7 Jun 2023 |
| 38 | BindCraft BindCraft | EPFL | +0.89 | 0.00 | 0.89 | 1 | 27 Aug 2025 |
| 39 | GPT-5.6 GPT-5.6 · version unspecified | OpenAI | +0.66 | 0.00 | 0.66 | 2 | 24 Sep 2026 |
| 40 | Queen of Hearts Queen of Hearts | Powerful Medical | +0.57 | 0.00 | 0.57 | 1 | 4 Sep 2026 |
| 41 | Boltz-1 Boltz | Massachusetts Institute of Technology | +0.52 | 0.00 | 0.52 | 1 | 19 Nov 2024 |
| 42 | AlphaFold 2 AlphaFold | Google DeepMind | +0.51 | 0.00 | 0.51 | 1 | 27 Aug 2025 |
| 43 | GPT-5.6 Pro GPT-5.6 | OpenAI | +0.48 | 0.00 | 0.48 | 2 | 30 Jul 2026 |
| 44 | WeatherNext 3 GraphCast | Google DeepMind | +0.42 | 0.00 | 0.42 | 1 | 3 Sep 2026 |
| 45 | GPT-5.6 Sol GPT-5.6 | OpenAI | +1.48 | −1.08 | 0.40 | 6 | 8 Sep 2026 |
| 46 | GPT-4 GPT | OpenAI | +0.40 | 0.00 | 0.40 | 2 | 8 May 2024 |
| 47 | Literature NLP Recipe Model Materials NLP | Lawrence Berkeley National Laboratory | +0.37 | 0.00 | 0.37 | 1 | 29 Nov 2023 |
| 48 | Chemprop Ensemble Internal Research Model Chemprop · internal / unreleased | Massachusetts Institute of Technology | +0.35 | 0.00 | 0.35 | 1 | 20 Dec 2023 |
| 49 | Claude Claude · version unspecified | Anthropic | +3.30 | −2.98 | 0.32 | 9 | 27 Oct 2026 |
| 50 | Chai-1 Chai | Chai Discovery | +0.32 | 0.00 | 0.32 | 2 | 21 Sep 2026 |
| 51 | GPT-5 GPT | OpenAI | +0.32 | 0.00 | 0.32 | 1 | 20 Nov 2025 |
| 52 | AMIE Gemini/PaLM medical | Google DeepMind | +0.29 | 0.00 | 0.29 | 1 | 9 Apr 2025 |
| 53 | Gemini Deep Think Gemini | Google DeepMind | +0.27 | 0.00 | 0.27 | 1 | 11 Feb 2026 |
| 54 | Evo 2 Evo | Arc Institute | +0.24 | 0.00 | 0.24 | 1 | 19 Feb 2025 |
| 55 | WeatherNext 2 GraphCast | Google DeepMind | +0.24 | 0.00 | 0.24 | 1 | 17 Nov 2025 |
| 56 | SL2T SL2T | Google DeepMind | +0.24 | 0.00 | 0.24 | 1 | 12 Aug 2026 |
| 57 | Pharma.AI Internal Research Model Pharma.AI · internal / unreleased | Insilico Medicine | +0.17 | 0.00 | 0.17 | 1 | 3 Jun 2025 |
| 58 | AlphaEarth Foundations AlphaEarth | Google DeepMind | +0.16 | 0.00 | 0.16 | 1 | 30 Jul 2025 |
| 59 | AlphaProof AlphaProof | Google DeepMind | +0.14 | 0.00 | 0.14 | 1 | 21 May 2026 |
| 60 | Ganeshram–Duruisseaux–Anandkumar PINN PINN | California Institute of Technology | +0.12 | 0.00 | 0.12 | 1 | 9 Sep 2026 |
| 61 | Chemprop-style Internal Research Model Chemprop · internal / unreleased | Massachusetts Institute of Technology | +0.08 | 0.00 | 0.08 | 1 | 25 May 2023 |
| 62 | Green Light Traffic Model Google Maps models | Google | +0.07 | 0.00 | 0.07 | 1 | 10 Oct 2023 |
| 63 | Gemini 2.0 Gemini | Google DeepMind | +0.04 | 0.00 | 0.04 | 1 | 19 Feb 2025 |
| 64 | Gemini 3.0 Flash Gemini | Google DeepMind | +0.03 | 0.00 | 0.03 | 1 | 21 May 2026 |
| 65 | Air Canada Website Chatbot Unknown commercial chatbot | Air Canada | 0.00 | −0.11 | -0.11 | 1 | 14 Feb 2024 |
| 66 | Tessa Cass chatbot | National Eating Disorders Association | 0.00 | −0.12 | -0.12 | 1 | 30 May 2023 |
| 67 | ElevenLabs Voice Model ElevenLabs | ElevenLabs | 0.00 | −0.18 | -0.18 | 1 | 21 Jan 2024 |
| 68 | Anthropic Internal Research Test Model — 2026 Claude · internal / unreleased | Anthropic | 0.00 | −0.23 | -0.23 | 1 | 30 Jul 2026 |
| 69 | Claude Opus 4.6 Claude | Anthropic | 0.00 | −0.23 | -0.23 | 1 | 30 Jul 2026 |
| 70 | Grok Grok | xAI | 0.00 | −0.24 | -0.24 | 1 | 8 Jul 2025 |
| 71 | Microsoft Designer Designer | Microsoft | 0.00 | −0.26 | -0.26 | 1 | 25 Jan 2024 |
| 72 | Claude Opus 4.7 Claude | Anthropic | +0.08 | −0.56 | -0.48 | 2 | 18 Sep 2026 |
| 73 | Claude Mythos 5 Claude | Anthropic | 0.00 | −0.76 | -0.76 | 2 | 30 Jul 2026 |
| 74 | OpenAI Internal Research System — 2026-05 (wiki swarm) OpenAI Internal · internal / unreleased | OpenAI | 0.00 | −0.78 | -0.78 | 2 | 12 May 2026 |
| 75 | Unknown Deepfake System Unknown generative media models | Unknown | 0.00 | −0.84 | -0.84 | 1 | 15 Jan 2024 |
| 76 | nH Predict nH Predict | UnitedHealth Group | 0.00 | −1.26 | -1.26 | 1 | 14 Nov 2023 |
| 77 | Character.AI Dialogue Model Character.AI | Character.AI | 0.00 | −1.54 | -1.54 | 1 | 28 Feb 2024 |
| 78 | OpenAI Internal Research System — 2026-07 (cyber evals) OpenAI Internal · internal / unreleased | OpenAI | 0.00 | −1.66 | -1.66 | 1 | 21 Jul 2026 |
| 79 | Unspecified AI system Unspecified · version unspecified | Unknown | +2.86 | −5.18 | -2.32 | 310 | 29 Oct 2026 |
| 80 | GPT-4o GPT | OpenAI | +0.01 | −2.77 | -2.76 | 4 | 17 Sep 2026 |
| 81 | Cruise ADS Cruise autonomous driving system | Cruise | 0.00 | −3.08 | -3.08 | 1 | 2 Oct 2023 |
