AlphaFold
A family is a named generation or product line. Scores below are the sum of its named releases and any documented internal systems in the same line.
Benefit
+13.93
Harm
0.00
Net Good
13.93
Releases
Leaderboard
| Rank | Model | Organization | Benefit | Harm | Net | Events | Last impact |
|---|---|---|---|---|---|---|---|
| 4 | AlphaFold 3 | Google DeepMind | +10.77 | 0.00 | 10.77 | 1 | 8 May 2024 |
| 13 | AlphaMissense | Google DeepMind | +2.65 | 0.00 | 2.65 | 1 | 19 Sep 2023 |
| 42 | AlphaFold 2 | Google DeepMind | +0.51 | 0.00 | 0.51 | 1 | 27 Aug 2025 |
Timeline
- Benefit
- Harm
- Net
Events
BindCraft designs nanomolar binders without high-throughput screening
EPFL-led BindCraft, published in Nature on 27 August 2025, used AlphaFold2 weights to design binders with 10–100 percent experimental success across diverse targets, including allergen, Cas9, toxin, and AAV applications.
AlphaFold 3 predicts structures of proteins bound to DNA, RNA, and ligands
Google DeepMind and Isomorphic Labs published AlphaFold 3 in Nature, extending structure prediction from proteins to complexes that include nucleic acids, small molecules, ions, and modified residues.
AlphaMissense classifies most possible human missense variants
DeepMind released AlphaMissense and a catalog covering about 71 million human missense variants, classifying 89 percent as likely benign or likely pathogenic, in Science on 19 September 2023.