Unspecified
A family is a named generation or product line. Scores below are the sum of its named releases and any documented internal systems in the same line.
Benefit
+0.07
Harm
−0.00
Net Good
0.07
Releases
- Unspecified AI systemVersion unspecified
Leaderboard
| Rank | Model | Organization | Benefit | Harm | Net | Events | Last impact |
|---|---|---|---|---|---|---|---|
| 58 | Unspecified AI system Unspecified · version unspecified | Unknown | +0.07 | −0.00 | 0.07 | 69 | 13 Sep 2026 |
Timeline
- Benefit
- Harm
- Net
Events
OmniTCR: a foundation model unifying T cell receptor recognition prediction and conditional sequence generation
T cell receptor (TCR) recognition prediction and receptor generation are traditionally modelled separately, leaving vast TCR sequence collections disconnected from smaller TCR-peptide-MHC datasets. Here we present OmniTCR, a 113-million-parameter autoregressive foundation model pretrained on 328 million formatted human immune-sequence records. Sequence-type tokens and complementary component orders enable joint learning from individual TCR chains and partial or complete TCR-pMHC associations. On unseen epitopes, OmniTCR achieved AUPRCs of 0.7009 for peptide-TCR{beta}; recognition and 0.8235 fo
Garry Tan wants US open-weight AI labs to 'distill' frontier models, too
Article URL: https://techcrunch.com/2026/09/11/y-combinators-garry-tan-wants-u-s-open-weight-ai-labs-to-distill-frontier-models-too/ Comments URL: https://news.ycombinator.com/item?id=49685253 Points: 269 # Comments: 136
There Is No AI (It's Just People) with Jaron Lanier
Article URL: https://singjupost.com/startalk-there-is-no-ai-really-its-just-people-w-jaron-lanier-transcript/ Comments URL: https://news.ycombinator.com/item?id=49687869 Points: 41 # Comments: 44
Towards reconstruction of the human interactome from positive and negative experimental evidence
Protein-protein interactions (PPIs) have been detected and reported in the millions, but while they are used in many different contexts for better understanding cellular processes in health and disease, the knowledge of the human PPI network is far from complete, containing many false positive measurements and being highly biased. Both to chart the extent of those problems and to solve them requires not just a knowledge of high-confidence positive interactions, but also likely non-interacting protein pairs. However, this information is typically not reported in PPI studies. We developed a meth
AI recursive self-improvement might not come so quickly after all (August 2026)
Article URL: https://www.technologyreview.com/2026/08/18/1142188/ai-recursive-self-improvement/ Comments URL: https://news.ycombinator.com/item?id=49687334 Points: 36 # Comments: 31
AI Is Destroying the World
Article URL: https://gornak40.org/blog/ai-is-destroying-the-world.html Comments URL: https://news.ycombinator.com/item?id=49688681 Points: 5 # Comments: 0
pydreg: a fast Python package for identifying active cis-regulatory elements from nascent transcription
Background: Active promoters and enhancers generate characteristic patterns of RNA transcription that can be measured through nascent RNA sequencing. dREG is a leading method that uses these patterns to identify active cis-regulatory elements across the genome, allowing regulatory activity and gene transcription to be profiled in the same experiment. However, its reference implementation was developed around an R-based workflow and a legacy GPU-accelerated support vector machine library that have become increasingly difficult to maintain and deploy. Findings: To improve future usability of dRE
Detection-Guided Beamforming for Efficient Bat Localisation
Passive acoustic monitoring is widely used to study wildlife, but current approaches provide limited insight into the spatial behaviour of animals. In bat ecology, reconstructing flight trajectories is essential for studying habitat use, movement patterns, and interactions, yet it remains difficult to achieve under field conditions. Acoustic cameras offer a potential solution by enabling sound source localisation, but their practical application is limited by the computational cost of beamforming and by the non-stationary, broadband, and transient nature of echolocation calls. In particular, e