What happened
Eight months after the AlphaGenome Nature paper, DeepMind published a 1-petabyte precomputed map covering the three substitutions at every hg38 base (~9 billion SNVs) and more than 100 million observed short insertions and deletions. The Atlas adds an AlphaGenome Variant Impact (AVI) score that compresses AlphaGenome regulatory predictions with AlphaMissense and conservation features into one ranking number, and a no-code portal for non-commercial research. Nature reported that the AVI score separated known pathogenic from benign variants in ClinVar-style tests in a DeepMind preprint, and that Broad Institute researchers used Atlas predictions to prioritize a non-coding candidate in a severe epilepsy case. This is not a diagnostic device and not a second score for the January 2026 method paper; it is the public, genome-wide lookup resource built from that model. Realization is a research database, not clinical care.