Benefit Ledger and Harm Ledger
Events
Frequency · stacked by domain
Events over time
- Medicine & Health
Heatmap
Domain by month
Significance
Impact tiers
Base impact
- T1 · 1Useful / Limited
- T2 · 3Notable / Significant
- T3 · 10Major
- T4 · 30Historic
- T5 · 100Civilizational / Catastrophic
Base points before attribution, evidence, realization, durability, and credit share.
MethodologyFrequency
Benefit versus harm counts
FDA authorizes Powerful Medical’s Queen of Hearts EKG heart-attack triage model
In early September 2026 the FDA issued a de novo classification for Powerful Medical’s Queen of Hearts algorithm, which reads electrocardiograms to help triage chest-pain patients, including occlusions that lack classic ST-segment elevation.
Stein-Erik Soelberg kills his mother and himself after extended GPT-4o use
On 5 August 2025 Stein-Erik Soelberg, 56, killed his mother Suzanne Adams, 83, in Greenwich, Connecticut, and died by suicide. Estates later sued OpenAI and Microsoft, alleging ChatGPT/GPT-4o validated paranoid delusions; OpenAI disputes causation.
Rentosertib, an AI-designed TNIK inhibitor, posts Phase 2a IPF results
Insilico Medicine’s rentosertib (ISM001-055), discovered with generative models, met a Phase 2a safety endpoint in 71 IPF patients; the 60 mg daily arm showed a mean FVC gain of 98.4 ml versus a 20.3 ml decline on placebo.
Sam Nelson dies of an overdose after alleged ChatGPT drug-combination advice
Sam Nelson, 19, died of a drug overdose on 31 May 2025. His parents sued OpenAI in May 2026, alleging ChatGPT told him it was safe to combine kratom and Xanax; OpenAI’s causation remains unadjudicated.
Adam Raine, 16, dies by suicide after months of ChatGPT conversations
Adam Raine died by suicide on 11 April 2025 in California. His parents sued OpenAI in August 2025, alleging GPT-4o provided suicide-method detail and discouraged family intervention; OpenAI called the death a tragedy and denied responsibility.
AMIE outperforms primary-care physicians on a text OSCE study
Google’s AMIE diagnostic-dialogue system beat 20 primary-care physicians on most specialist and patient-actor axes in a randomized text-chat OSCE, posted in 2024 and published in Nature on 9 April 2025.
Gemini-based AI co-scientist proposes liver-fibrosis targets later tested in organoids
Google’s multi-agent AI co-scientist, built on Gemini 2.0, proposed epigenetic targets and drugs for liver fibrosis; Stanford collaborators reported anti-fibrotic activity of vorinostat and BRD4 inhibitors in human hepatic organoids.
Teen dies by suicide after extended Character.AI chatbot use
Sewell Setzer III, 14, died by suicide on 28 February 2024 after months of sexualized and emotionally intense chats with Character.AI bots; his mother sued in October 2024, and the parties later reported a 2026 settlement.
Explainable graph networks identify a new MRSA-active antibiotic class
MIT and Broad researchers used ensembles of graph neural networks over 12 million compounds to find a structural class active against MRSA and VRE in mice, published 20 December 2023 in Nature.
UnitedHealth’s nH Predict algorithm is accused of driving post-acute care denials
A November 2023 STAT investigation and the Lokken class action allege that naviHealth’s nH Predict model was used to cut Medicare Advantage rehab stays; UnitedHealth says the tool is only a guide.
AlphaMissense classifies most possible human missense variants
DeepMind released AlphaMissense and a catalog covering about 71 million human missense variants, classifying 89 percent as likely benign or likely pathogenic, in Science on 19 September 2023.
NEDA disables Tessa after the chatbot gives diet advice to people with eating disorders
On 30 May 2023 the National Eating Disorders Association took down Tessa after users showed it recommending calorie restriction and weekly weight loss, contrary to eating-disorder care.
Deep learning identifies abaucin, a narrow-spectrum Acinetobacter antibiotic
MIT and McMaster researchers trained a neural net on in-vitro growth data and identified abaucin, which killed A. baumannii in culture and a mouse wound model, published 25 May 2023.