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RoseTTAFold All-Atom models proteins together with ligands, nucleic acids, and covalent modifications

The Baker lab’s RoseTTAFold All-Atom, published in Science in March 2024, extended structure prediction and design to full biomolecular assemblies including small molecules and nucleic acids.

7 Mar 2024Tier 3 MajorMethodology 0.1

Current score

+1.94

10 base · Major (tier 3 of 5, 10 pts)
× 0.8000 attribution · Primary causal contribution
× 0.7000 evidence · Peer review or independent validation
× 0.5500 realization · Experimentally validated
× 0.7000 durability
Event-level product before credit split: 2.16

Major all-atom modeling/design method (tier 3). High attribution. Science plus experiments. Research realization.

What happened

The method was used both to predict complexes and to design proteins that bind specified small molecules, with experimental characterization of some designs. It sits alongside AlphaFold 3 as a contemporaneous all-atom approach with public academic tooling.

Model attribution

+1.94

RoseTTAFold

All-atom structure prediction and design network.

The published network is the method.

Attribution 0.8000 · Credit share 90% · University of Washington Institute for Protein Design

Claims

  • RoseTTAFold All-Atom predicted and in some cases designed biomolecular assemblies including non-protein components with experimental follow-up.

    outcome · supported

Sources

primary sources

Secondary domains: Chemistry

Revision history

  • 13 Sep 2026 · 0.00 → 1.94

    Initial adjudicated seed score under methodology 0.1.

RoseTTAFold All-Atom models proteins together with ligands, nucleic acids, and covalent modifications · NetGoodIndex