NetGoodIndexSubmit a correction

Benefit Ledger · verified · Biology

Evo designs functional CRISPR-Cas and transposon systems from DNA

Arc Institute and Stanford’s Evo genomic model, published in Science on 14 November 2024, generated protein–RNA and protein–DNA systems that showed activity in experimental tests.

14 Nov 2024Tier 3 MajorMethodology 0.1

Current score

+1.67

10 base · Major (tier 3 of 5, 10 pts)
× 0.8000 attribution · Primary causal contribution
× 0.7000 evidence · Peer review or independent validation
× 0.5000 realization · Experimentally validated
× 0.7000 durability
Event-level product before credit split: 1.96

First peer-reviewed DNA LM with functional multi-molecule codesign (tier 3). High attribution with human assays. Science. Realization is lab constructs. Durable sequences and method.

What happened

Evo is a 7B StripedHyena model trained on prokaryotic and phage genomes at single-nucleotide resolution with 131 kb context. The paper reported zero-shot function prediction and experimental activity of generated CRISPR-Cas complexes and IS200/IS605-like transposons. Genome-scale generation claims are computational. Safety discussion was included because the model can propose biological systems.

Model attribution

+1.67

Evo

Long-context DNA model that generated CRISPR and transposon systems later tested.

Model generated sequences; experimental validation was human-led.

Attribution 0.8000 · Credit share 85% · Arc Institute

Claims

  • Evo-generated CRISPR-Cas and transposon systems showed functional activity in reported experiments.

    outcome · supported

Sources

primary sources

Secondary domains: Medicine & Health

Revision history

  • 13 Sep 2026 · 0.00 → 1.67

    Initial adjudicated seed score under methodology 0.1.