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Competitive BLI found 20/91 disruptor hits, three of which removed more soluble IgE than omalizumab at 25–400 nM, plus three de novo anchors. The arms have not been paired, cells and animals were not tested, and the designs did not beat parent sdAb026 at controlled doses.","ledger_type":"benefit","event_status":"provisional","event_date":"2026-10-27","base_impact_tier":3,"domain":"Biology","domain_slug":"biology","score":0.7219},{"slug":"claude-gtg20006-ukraine-europe-espionage","title":"Russian-nexus operators use Claude to run espionage against Ukraine and European targets","short_summary":"Anthropic’s September 2026 threat report describes GTG-20006, a Russian-speaking actor it links to Midnight Blizzard tradecraft, using Claude-driven workflows to phish, persist, and exfiltrate data from more than 20 organizations concentrated in Ukraine and Europe, including government, diplomatic, and drone-supply-chain victims.","ledger_type":"harm","event_status":"provisional","event_date":"2026-09-10","base_impact_tier":3,"domain":"Safety","domain_slug":"safety","score":0.9625},{"slug":"claude-lakana-360-mali-surveillance","title":"A consultant uses Claude to engineer Mali’s Lakana 360 mass-interception platform","short_summary":"Anthropic’s September 2026 threat report says a likely Bamako-based consultant working with Mali’s ANSE used Claude as the primary engineering workforce for Lakana 360, a platform designed to monitor about 25 million SIM cards across Mali’s mobile operators and generate dossiers without a court order.","ledger_type":"harm","event_status":"provisional","event_date":"2026-09-10","base_impact_tier":3,"domain":"Safety","domain_slug":"safety","score":1.1375},{"slug":"claude-shinyhunters-theft-extortion","title":"Anthropic disrupts Claude-assisted ShinyHunters theft and extortion campaigns","short_summary":"Anthropic’s September 2026 threat report says financially motivated operators suspected as ShinyHunters affiliates used Claude Haiku, Sonnet, and Opus models to steal data at scale—including more than a terabyte from one technology provider, millions of payment-card records, and tens of millions of airline passenger records—then extort victims.","ledger_type":"harm","event_status":"provisional","event_date":"2026-09-10","base_impact_tier":3,"domain":"Economics & Productivity","domain_slug":"economics-productivity","score":0.875},{"slug":"buckmaster-alpoge-smooth-forced-fluid-blowup","title":"Buckmaster and Alpöge, using Sol and Claude, prove smooth-forced blowup for Euler, IPM, and Boussinesq","short_summary":"On 8–11 September 2026 Tristan Buckmaster and Levent Alpöge released Lean-backed finite-time blowup results with smooth forcing for incompressible porous media, 2D Boussinesq, and 3D Euler, crediting Anthropic’s Claude and especially OpenAI’s GPT-5.6 Sol. Astra was used only for writeups and auditing.","ledger_type":"benefit","event_status":"provisional","event_date":"2026-09-08","base_impact_tier":3,"domain":"Mathematics","domain_slug":"mathematics","score":0.4331},{"slug":"alpoge-claude-complex-structure-s6","title":"Alpöge credits Claude with a claimed complex structure on S^6","short_summary":"In late August 2026 Levent Alpöge posted a manuscript, produced with Claude, claiming a compact complex threefold diffeomorphic to the six-sphere. Independent writeups and a Lean formalization effort followed; expert review is ongoing and the claim is treated as disputed.","ledger_type":"benefit","event_status":"disputed","event_date":"2026-08-23","base_impact_tier":3,"domain":"Mathematics","domain_slug":"mathematics","score":0.546},{"slug":"claude-alpoge-howell-elliptic-rank-31","title":"Claude, with Alpöge and Howell, posts rank ≥30 and ≥31 elliptic curves over Q","short_summary":"On 20 and 23 August 2026 the ICARM elliptic-curve rank leaderboard recorded new records of rank at least 30 and 31, with public witness points, credited to Claude working with Levent Alpöge and Ava Howell. Exact rank 30/31 is reported only under GRH and BSD.","ledger_type":"benefit","event_status":"provisional","event_date":"2026-08-20","base_impact_tier":3,"domain":"Mathematics","domain_slug":"mathematics","score":1.4823},{"slug":"claude-hadamard-matrix-668","title":"A three-human plus Claude team is reported to construct a Hadamard matrix of order 668","short_summary":"In August 2026 Epoch’s open-problems index listed a Hadamard matrix of order 668 as Solved (AI) by a three-human plus Claude team, while the dedicated problem page still appeared to say open. The construction is included as disputed until those sources agree.","ledger_type":"benefit","event_status":"disputed","event_date":"2026-08-12","base_impact_tier":2,"domain":"Mathematics","domain_slug":"mathematics","score":0.0945},{"slug":"coscientist-gpt4-autonomous-chemistry","title":"Coscientist uses GPT-4 to plan and run robotic chemistry experiments","short_summary":"Carnegie Mellon researchers showed a GPT-4-driven agent, Coscientist, that searched literature, wrote robot code, and optimized palladium-catalyzed couplings, published in Nature on 20 December 2023.","ledger_type":"benefit","event_status":"verified","event_date":"2023-12-20","base_impact_tier":2,"domain":"Chemistry","domain_slug":"chemistry","score":0.0217}],"domains":[{"name":"Mathematics","slug":"mathematics","benefit":2.5559,"harm":0},{"name":"Chemistry","slug":"chemistry","benefit":0.0217,"harm":0},{"name":"Biology","slug":"biology","benefit":0.7219,"harm":0},{"name":"Safety","slug":"safety","benefit":0,"harm":2.1},{"name":"Economics & 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