{"data":{"event":{"id":"dff20d88-8a52-4191-99be-f03c18832c16","slug":"rosettafold-all-atom-biomolecules","title":"RoseTTAFold All-Atom models proteins together with ligands, nucleic acids, and covalent modifications","short_summary":"The Baker lab’s RoseTTAFold All-Atom, published in Science in March 2024, extended structure prediction and design to full biomolecular assemblies including small molecules and nucleic acids.","full_description":"The method was used both to predict complexes and to design proteins that bind specified small molecules, with experimental characterization of some designs. It sits alongside AlphaFold 3 as a contemporaneous all-atom approach with public academic tooling.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"verified","event_date":"2024-03-07T00:00:00.000Z","discovery_date":"2024-03-07T00:00:00.000Z","first_published_date":"2024-03-07T00:00:00.000Z","last_reviewed_date":"2024-03-07T00:00:00.000Z","geographic_scope":"Global structural-biology research","affected_population":"Academic protein designers","base_impact_tier":3,"base_score":"10.00","attribution_multiplier":"0.8000","evidence_multiplier":"0.7000","realization_multiplier":"0.5500","durability_multiplier":"0.7000","current_event_score":"1.940400","confidence_level":"high","score_explanation":"Major all-atom modeling/design method (tier 3). High attribution. Science plus experiments. Research realization.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2024-03-07T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"a05c641a-cc6b-491e-ba3a-5ff3e800c7e4","event_id":"dff20d88-8a52-4191-99be-f03c18832c16","model_id":"7e053fce-8899-4f65-ad66-99977737a012","role_description":"All-atom structure prediction and design network.","attribution_multiplier":"0.8000","credit_share":"0.9000","contribution_score":"1.940400","attribution_rationale":"The published network is the method.","attribution_confidence":"medium","first_used_date":"2024-03-07T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"rosettafold-all-atom","model_name":"RoseTTAFold All-Atom","identity_class":"named_release","is_internal":false,"family_name":"RoseTTAFold","family_slug":"uw-institute-for-protein-design-rosettafold","organization_name":"University of Washington Institute for Protein Design","organization_slug":"uw-institute-for-protein-design"}],"sources":[{"id":"edf4e973-3277-441c-8472-be44e4488bf5","event_id":"dff20d88-8a52-4191-99be-f03c18832c16","url":"https://www.science.org/doi/10.1126/science.adl2528","canonical_url":"https://www.science.org/doi/10.1126/science.adl2528","source_type":"peer_reviewed","publisher":"Science","author":null,"publication_date":"2024-03-07T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Generalized biomolecular modeling and design with RoseTTAFold All-Atom","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"844efef1-3718-4818-9542-376f6001c28c","event_id":"dff20d88-8a52-4191-99be-f03c18832c16","claim_text":"RoseTTAFold All-Atom predicted and in some cases designed biomolecular assemblies including non-protein components with experimental follow-up.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"90fe1536-54bf-4d35-8ff3-cee71178cf8f","event_id":"dff20d88-8a52-4191-99be-f03c18832c16","model_id":null,"previous_score":"0.000000","new_score":"1.940400","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":10,"durability":0.7,"attribution":0.8,"realization":0.55},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Chemistry","slug":"chemistry"}]},"methodology_version":"0.1"}