{"data":{"event":{"id":"393a6a43-c77b-47bb-ad06-b511773f1b37","slug":"opencrispr-1-ai-gene-editor","title":"OpenCRISPR-1 edits the human genome with an AI-designed Cas effector","short_summary":"Profluent’s language-model-designed OpenCRISPR-1 showed Cas9-like editing in human cells and base-editor compatibility, posted in 2024 and published in Nature on 30 July 2025.","full_description":"Models trained on more than one million mined CRISPR operons generated Cas-like proteins hundreds of mutations from SpCas9. OpenCRISPR-1 was characterized for on-target activity, PAM preference, and reduced off-target editing in the authors’ assays, and released for research use. 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