{"data":{"event":{"id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","slug":"google-ai-coscientist-liver-fibrosis","title":"Gemini-based AI co-scientist proposes liver-fibrosis targets later tested in organoids","short_summary":"Google’s multi-agent AI co-scientist, built on Gemini 2.0, proposed epigenetic targets and drugs for liver fibrosis; Stanford collaborators reported anti-fibrotic activity of vorinostat and BRD4 inhibitors in human hepatic organoids.","full_description":"A February 2025 preprint described tournament-style hypothesis generation. A related bioRxiv study (April 2025) tested AI-suggested epigenetic interventions in micro-human hepatic organoids. Findings are preclinical and do not establish a new standard of care. Novelty of the hypotheses versus prior HDAC/BRD4 fibrosis literature is debated.","ledger_type":"benefit","primary_domain_id":"c09546b6-10f8-48df-8347-0c1979416464","event_status":"provisional","event_date":"2025-02-19T00:00:00.000Z","discovery_date":"2025-02-19T00:00:00.000Z","first_published_date":"2025-02-19T00:00:00.000Z","last_reviewed_date":"2025-02-19T00:00:00.000Z","geographic_scope":"USA laboratory collaboration","affected_population":"Preclinical liver-fibrosis researchers","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.4000","evidence_multiplier":"0.3500","realization_multiplier":"0.4500","durability_multiplier":"0.4000","current_event_score":"0.037800","confidence_level":"medium","score_explanation":"Notable hypothesis-to-organoid loop (tier 2). Modest attribution because HDAC/BRD4 ideas preexist and humans ran assays. Preprint-level evidence. Realization is organoid, not patients. Provisional pending peer review of the full causal story.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2025-02-19T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Medicine & Health","domain_slug":"medicine-health","methodology_version":"0.1"},"contributions":[{"id":"dce10998-7ad5-4244-88fe-4bdda0ba6966","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","model_id":"4ce5b589-54c3-4ea2-8c50-b42332323112","role_description":"Backbone of the multi-agent co-scientist that ranked fibrosis hypotheses and drug classes.","attribution_multiplier":"0.4000","credit_share":"0.5000","contribution_score":"0.037800","attribution_rationale":"System proposed testable epigenetic hypotheses; wet-lab validation and much prior literature were human.","attribution_confidence":"medium","first_used_date":"2025-02-19T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"gemini-2-0","model_name":"Gemini 2.0","identity_class":"named_release","is_internal":false,"family_name":"Gemini","family_slug":"google-deepmind-gemini","organization_name":"Google DeepMind","organization_slug":"google-deepmind"}],"sources":[{"id":"4e05b32b-e424-4b85-bb54-4f581e64153b","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","url":"https://research.google/blog/accelerating-scientific-breakthroughs-with-an-ai-co-scientist/","canonical_url":"https://research.google/blog/accelerating-scientific-breakthroughs-with-an-ai-co-scientist/","source_type":"developer_announcement","publisher":"Google Research","author":null,"publication_date":"2025-02-19T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Accelerating scientific breakthroughs with an AI co-scientist","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"ba60cf45-bb69-44a8-9971-3d1ca26bda1c","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","url":"https://arxiv.org/abs/2502.18864","canonical_url":"https://arxiv.org/abs/2502.18864","source_type":"preprint","publisher":"arXiv","author":null,"publication_date":"2025-02-26T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Towards an AI co-scientist","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"b327ac53-b6a1-4df1-8e9a-7a92439fe5f2","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","url":"https://www.biorxiv.org/content/10.1101/2025.04.29.651320v1","canonical_url":"https://www.biorxiv.org/content/10.1101/2025.04.29.651320v1","source_type":"preprint","publisher":"bioRxiv","author":null,"publication_date":"2025-04-29T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"AI co-scientist liver fibrosis organoid study","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"ae623866-cbf4-4269-a9ec-ee4be5a68e7a","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","claim_text":"The co-scientist suggested HDAC and BRD4 inhibition for liver fibrosis, and organoid experiments showed anti-fibrotic effects for some suggested agents.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"},{"id":"3c1b5c6a-fb22-47cf-b16b-505ce22da1bb","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","claim_text":"The system discovered a previously unknown biological mechanism with no prior literature.","claim_type":"significance","claim_status":"disputed","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"6f8cc2d2-a263-4c35-80ab-2d1cff843ea3","event_id":"91e73e94-9470-4dec-b6e4-3fd77c02947b","model_id":null,"previous_score":"0.000000","new_score":"0.037800","previous_factors":{},"new_factors":{"evidence":0.35,"base_score":3,"durability":0.4,"attribution":0.4,"realization":0.45},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Biology","slug":"biology"}]},"methodology_version":"0.1"}