{"data":{"event":{"id":"0d1e887c-234c-49df-87f4-d95724b28c3b","slug":"expressing-glycan-motifs-as-a-containment-order-increases-sensitivity-an-ab0e8369e3","title":"\n\nExpressing glycan motifs as a containment order increases sensitivity and uncovers motif redistributions \n\n","short_summary":"Glycan motifs are the standard readout of comparative glycomics, and pipelines treat them as independent features. Here, we show they are not. Motifs are partially ordered by substructure containment, so a parent motif's abundance dominates each of its children. We make that order explicit as a directed acyclic graph, which stratifies the multiple-testing family correctly and, together with an empirical-Bayes variance prior taken from each motif's containment neighborhood, raises estimated true positives across 45 glycomics datasets from 300 to 442 (+47%, p = 0.0001) after controlling for perm","full_description":"Glycan motifs are the standard readout of comparative glycomics, and pipelines treat them as independent features. Here, we show they are not. Motifs are partially ordered by substructure containment, so a parent motif's abundance dominates each of its children. We make that order explicit as a directed acyclic graph, which stratifies the multiple-testing family correctly and, together with an empirical-Bayes variance prior taken from each motif's containment neighborhood, raises estimated true positives across 45 glycomics datasets from 300 to 442 (+47%, p = 0.0001) after controlling for permutation-null false positives. Because a parent's children and its residual form a genuine sub-composition, their logratio balances need no reference frame and no scale model, and they separate a motif's own change from one inherited from its contexts. Of 337 significant parent motifs, 150 (45%) thus carry no signal of their own, while 138 motifs move only in the decomposition. We present case studies for both glycomics and glycoproteomics, including a recurrent reapportioning of core-1 sialylation at the immune-inhibitory disialyl-T antigen across eight human O-glycomes, and a colorectal fucosylation shift confined to the antenna, neither of which any marginal analysis reports.","ledger_type":"benefit","primary_domain_id":"fc7d617f-c9df-4b9f-b595-4408915ea380","event_status":"provisional","event_date":"2026-09-15T00:00:00.000Z","discovery_date":"2026-09-15T00:00:00.000Z","first_published_date":"2026-09-15T00:00:00.000Z","last_reviewed_date":"2026-09-15T00:00:00.000Z","geographic_scope":"International","affected_population":null,"base_impact_tier":1,"base_score":"1.00","attribution_multiplier":"0.1000","evidence_multiplier":"0.1000","realization_multiplier":"0.2000","durability_multiplier":"0.5000","current_event_score":"0.001000","confidence_level":"low","score_explanation":"Auto-published from news ingest as a provisional placeholder. 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Attribution stays unspecified until a release is identified.","attribution_confidence":"medium","first_used_date":"2026-09-15T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-16T06:00:52.753Z","model_slug":"unspecified-ai-system","model_name":"Unspecified AI system","identity_class":"unknown","is_internal":false,"family_name":"Unspecified","family_slug":"unknown-unspecified","organization_name":"Unknown","organization_slug":"unknown"}],"sources":[{"id":"6e423bf7-3bb6-42b6-b1a0-b165d677f8fd","event_id":"0d1e887c-234c-49df-87f4-d95724b28c3b","url":"\nhttps://www.biorxiv.org/content/10.64898/2026.09.10.750563v1?rss=1\n","canonical_url":"\nhttps://www.biorxiv.org/content/10.64898/2026.09.10.750563v1?rss=1\n","source_type":"preprint","publisher":"bioRxiv","author":null,"publication_date":"2026-09-15T00:00:00.000Z","retrieved_at":"2026-09-16T06:00:52.776Z","title":"\n\nExpressing glycan motifs as a containment order increases sensitivity and uncovers motif redistributions \n\n","excerpt":"Glycan motifs are the standard readout of comparative glycomics, and pipelines treat them as independent features. Here, we show they are not. Motifs are partially ordered by substructure containment, so a parent motif's abundance dominates each of its children. We make that order explicit as a directed acyclic graph, which stratifies the multiple-testing family correctly and, together with an empirical-Bayes variance prior taken from each motif's containment neighborhood, raises estimated true ","content_hash":null,"source_reliability_class":"medium","is_primary_source":true,"is_independent":true,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-16T06:00:52.776Z"}],"claims":[{"id":"24ef53f0-8932-4ab3-a3a7-2e2d59a920af","event_id":"0d1e887c-234c-49df-87f4-d95724b28c3b","claim_text":"\n\nExpressing glycan motifs as a containment order increases sensitivity and uncovers motif redistributions \n\n","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-16T06:00:52.787Z","updated_at":"2026-09-16T06:00:52.787Z"}],"revisions":[{"id":"bad47959-057b-4a39-96ab-7b79c92ab260","event_id":"0d1e887c-234c-49df-87f4-d95724b28c3b","model_id":null,"previous_score":"0.000000","new_score":"0.001000","previous_factors":{},"new_factors":{"evidence":0.1,"base_score":1,"durability":0.5,"attribution":0.1,"realization":0.2},"change_reason":"Auto-published from news ingest.","trigger_type":"news_ingest","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-16T06:00:52.801Z"}],"secondary":[]},"methodology_version":"0.1"}