{"data":{"event":{"id":"95562775-8e1c-42a7-9fc4-30892a55c650","slug":"evo-functional-crispr-transposon-design","title":"Evo designs functional CRISPR-Cas and transposon systems from DNA","short_summary":"Arc Institute and Stanford’s Evo genomic model, published in Science on 14 November 2024, generated protein–RNA and protein–DNA systems that showed activity in experimental tests.","full_description":"Evo is a 7B StripedHyena model trained on prokaryotic and phage genomes at single-nucleotide resolution with 131 kb context. The paper reported zero-shot function prediction and experimental activity of generated CRISPR-Cas complexes and IS200/IS605-like transposons. Genome-scale generation claims are computational. Safety discussion was included because the model can propose biological systems.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"verified","event_date":"2024-11-14T00:00:00.000Z","discovery_date":"2024-11-14T00:00:00.000Z","first_published_date":"2024-11-14T00:00:00.000Z","last_reviewed_date":"2024-11-14T00:00:00.000Z","geographic_scope":"Global genomic-design research","affected_population":"Genome-engineering researchers","base_impact_tier":3,"base_score":"10.00","attribution_multiplier":"0.8000","evidence_multiplier":"0.7000","realization_multiplier":"0.5000","durability_multiplier":"0.7000","current_event_score":"1.666000","confidence_level":"high","score_explanation":"First peer-reviewed DNA LM with functional multi-molecule codesign (tier 3). High attribution with human assays. Science. Realization is lab constructs. Durable sequences and method.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2024-11-14T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"40a2400e-12ae-4357-91a4-105a450d0916","event_id":"95562775-8e1c-42a7-9fc4-30892a55c650","model_id":"07e34169-2ac6-4185-be6d-889edc4f0156","role_description":"Long-context DNA model that generated CRISPR and transposon systems later tested.","attribution_multiplier":"0.8000","credit_share":"0.8500","contribution_score":"1.666000","attribution_rationale":"Model generated sequences; experimental validation was human-led.","attribution_confidence":"medium","first_used_date":"2024-02-27T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"evo","model_name":"Evo","identity_class":"named_release","is_internal":false,"family_name":"Evo","family_slug":"arc-institute-evo","organization_name":"Arc Institute","organization_slug":"arc-institute"}],"sources":[{"id":"b10ad859-7f67-4f5d-a9d8-be432b4d2a21","event_id":"95562775-8e1c-42a7-9fc4-30892a55c650","url":"https://arcinstitute.org/news/evo","canonical_url":"https://arcinstitute.org/news/evo","source_type":"university_announcement","publisher":"Arc Institute","author":null,"publication_date":"2024-02-27T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Evo: DNA foundation modeling from molecular to genome scale","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"6c09195c-fa81-46d8-9282-052f19df0b06","event_id":"95562775-8e1c-42a7-9fc4-30892a55c650","url":"https://www.science.org/doi/10.1126/science.ado9336","canonical_url":"https://www.science.org/doi/10.1126/science.ado9336","source_type":"peer_reviewed","publisher":"Science","author":null,"publication_date":"2024-11-14T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Sequence modeling and design from molecular to genome scale with Evo","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"72896a06-4212-4a89-8e9b-18332e77b892","event_id":"95562775-8e1c-42a7-9fc4-30892a55c650","claim_text":"Evo-generated CRISPR-Cas and transposon systems showed functional activity in reported experiments.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"a6933eed-915f-4903-8310-292e61f57b23","event_id":"95562775-8e1c-42a7-9fc4-30892a55c650","model_id":null,"previous_score":"0.000000","new_score":"1.666000","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":10,"durability":0.7,"attribution":0.8,"realization":0.5},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Medicine & Health","slug":"medicine-health"}]},"methodology_version":"0.1"}