{"data":{"event":{"id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","slug":"evo-2-cross-domain-genome-model","title":"Evo 2 extends genomic language modeling across domains of life","short_summary":"Arc Institute released Evo 2 on 19 February 2025 as a larger DNA foundation model trained across eukaryotic and prokaryotic genomes, with public weights and reports of improved variant-effect and sequence-generation behavior versus Evo 1.","full_description":"The announcement and accompanying paper described scaling to tens of billions of parameters and much longer genomic context, with experimental collaborators testing designed sequences. Independent clinical utility is not established. Treat as a methods and resource release.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"provisional","event_date":"2025-02-19T00:00:00.000Z","discovery_date":"2025-02-19T00:00:00.000Z","first_published_date":"2025-02-19T00:00:00.000Z","last_reviewed_date":"2025-02-19T00:00:00.000Z","geographic_scope":"Global genomics research","affected_population":"Computational biologists using open Evo 2 weights","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.8500","evidence_multiplier":"0.3500","realization_multiplier":"0.4500","durability_multiplier":"0.6000","current_event_score":"0.241000","confidence_level":"medium","score_explanation":"Notable open genomic foundation model (tier 2). High attribution. Developer/preprint evidence. Realization is a research model. Provisional pending broader peer-reviewed wet-lab claims.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2025-02-19T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"f2c8a559-b3c3-46d7-b703-504451945c59","event_id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","model_id":"b17ee2f4-ac64-4340-b522-1c032129eb77","role_description":"Scaled genomic foundation model released with weights.","attribution_multiplier":"0.8500","credit_share":"1.0000","contribution_score":"0.241000","attribution_rationale":"The released model is the contribution.","attribution_confidence":"medium","first_used_date":"2025-02-19T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"evo-2","model_name":"Evo 2","identity_class":"named_release","is_internal":false,"family_name":"Evo","family_slug":"arc-institute-evo","organization_name":"Arc Institute","organization_slug":"arc-institute"}],"sources":[{"id":"bafb6b1c-1532-45d4-a1e9-2ebb58c00c3e","event_id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","url":"https://arcinstitute.org/news/evo-2","canonical_url":"https://arcinstitute.org/news/evo-2","source_type":"university_announcement","publisher":"Arc Institute","author":null,"publication_date":"2025-02-19T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Evo 2","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"6222e36d-5582-4afd-ad9d-a63fe3e840e3","event_id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","url":"https://github.com/arcinstitute/evo2","canonical_url":"https://github.com/arcinstitute/evo2","source_type":"other","publisher":"GitHub / Arc Institute","author":null,"publication_date":"2025-02-19T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Evo 2 code repository","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"f61efbe5-cb53-466c-ac2f-090e918cea1d","event_id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","claim_text":"Evo 2 was publicly released as a cross-domain DNA foundation model with open weights.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"f8e5da96-3967-4378-bffb-b5a0a2fcb2cd","event_id":"fcee8c00-63bc-4dd0-8ca1-0e07258c99f6","model_id":null,"previous_score":"0.000000","new_score":"0.241000","previous_factors":{},"new_factors":{"evidence":0.35,"base_score":3,"durability":0.6,"attribution":0.85,"realization":0.45},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Medicine & Health","slug":"medicine-health"}]},"methodology_version":"0.1"}