{"data":{"event":{"id":"91b516ae-c675-4c23-a308-c1b44a657a5d","slug":"coscientist-gpt4-autonomous-chemistry","title":"Coscientist uses GPT-4 to plan and run robotic chemistry experiments","short_summary":"Carnegie Mellon researchers showed a GPT-4-driven agent, Coscientist, that searched literature, wrote robot code, and optimized palladium-catalyzed couplings, published in Nature on 20 December 2023.","full_description":"Coscientist combined GPT-4 with tools for web search, documentation, code execution, and lab APIs, including an Opentrons OT-2. Demonstrations included Suzuki–Miyaura and Sonogashira planning and reaction optimization with GC-MS confirmation. Claude was also used in some configurations. The work is a controlled lab demonstration, not a general autonomous scientist.","ledger_type":"benefit","primary_domain_id":"901fb1fb-04f9-453b-a00e-22cbd3fe517c","event_status":"verified","event_date":"2023-12-20T00:00:00.000Z","discovery_date":"2023-12-20T00:00:00.000Z","first_published_date":"2023-12-20T00:00:00.000Z","last_reviewed_date":"2023-12-20T00:00:00.000Z","geographic_scope":"Laboratory demonstration (USA)","affected_population":"Automation and digital-chemistry researchers","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.6000","evidence_multiplier":"0.7000","realization_multiplier":"0.5500","durability_multiplier":"0.5000","current_event_score":"0.264300","confidence_level":"high","score_explanation":"Notable automation result (tier 2). GPT-4 was necessary but humans built tools and hardware. Peer-reviewed demo. Realization is lab tasks, not new molecules in the clinic. Medium durability as agent stacks age quickly.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2023-12-20T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Chemistry","domain_slug":"chemistry","methodology_version":"0.1"},"contributions":[{"id":"a74b7593-2b1c-4eb3-a591-496199babaf1","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","model_id":"4bac22cf-53ad-427e-a527-7fd8cb24abb2","role_description":"Primary planner LLM that called tools and wrote experimental code.","attribution_multiplier":"0.6000","credit_share":"0.7000","contribution_score":"0.242600","attribution_rationale":"Paper describes a GPT-4-driven multi-LLM agent; humans supplied tools and robots.","attribution_confidence":"medium","first_used_date":"2023-04-01T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"gpt-4","model_name":"GPT-4","identity_class":"named_release","is_internal":false,"family_name":"GPT","family_slug":"openai-gpt","organization_name":"OpenAI","organization_slug":"openai"},{"id":"5f90f84b-0c59-468d-a556-3ad79c3a2d38","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","model_id":"059c33b6-fc2e-4d3d-acdb-c0d966ee5e6e","role_description":"Used as an additional LLM in some Coscientist configurations.","attribution_multiplier":"0.2500","credit_share":"0.1500","contribution_score":"0.021700","attribution_rationale":"CMU announcement and paper note Claude among usable LLMs; GPT-4 was primary.","attribution_confidence":"medium","first_used_date":"2023-12-20T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"claude","model_name":"Claude","identity_class":"unknown","is_internal":false,"family_name":"Claude","family_slug":"anthropic-claude","organization_name":"Anthropic","organization_slug":"anthropic"}],"sources":[{"id":"c689ae15-79bb-473c-adad-b74661b54735","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","url":"https://www.nature.com/articles/s41586-023-06792-0","canonical_url":"https://www.nature.com/articles/s41586-023-06792-0","source_type":"peer_reviewed","publisher":"Nature","author":null,"publication_date":"2023-12-20T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Autonomous chemical research with large language models","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"f03eecee-cd47-4797-bcfb-9635b4a92616","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","url":"https://www.cmu.edu/news/stories/archives/2023/december/cmu-designed-artificially-intelligent-coscientist-automates-scientific-discovery","canonical_url":"https://www.cmu.edu/news/stories/archives/2023/december/cmu-designed-artificially-intelligent-coscientist-automates-scientific-discovery","source_type":"university_announcement","publisher":"Carnegie Mellon University","author":null,"publication_date":"2023-12-20T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"CMU-Designed Artificially Intelligent Coscientist Automates Scientific Discovery","excerpt":null,"content_hash":null,"source_reliability_class":"medium","is_primary_source":true,"is_independent":true,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"f1e9c7c1-6eb9-4205-ab20-078bb1233990","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","claim_text":"Coscientist planned and executed palladium-catalyzed coupling experiments via robotic APIs.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"},{"id":"177e44e8-8ad6-4cbd-a405-686ea05f278b","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","claim_text":"GPT-4 was the primary language model in the published system.","claim_type":"attribution","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"5153574b-d7ce-4237-8ae6-ccd518090e65","event_id":"91b516ae-c675-4c23-a308-c1b44a657a5d","model_id":null,"previous_score":"0.000000","new_score":"0.264300","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":3,"durability":0.5,"attribution":0.6,"realization":0.55},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Computer Science","slug":"computer-science"}]},"methodology_version":"0.1"}