{"data":{"event":{"id":"bf7eeefc-7c03-4524-8d10-b67fa847ca2c","slug":"collins-explainable-mrsa-antibiotic-class","title":"Explainable graph networks identify a new MRSA-active antibiotic class","short_summary":"MIT and Broad researchers used ensembles of graph neural networks over 12 million compounds to find a structural class active against MRSA and VRE in mice, published 20 December 2023 in Nature.","full_description":"Models trained on 39,312 measured compounds predicted activity and cytotoxicity; explainable substructure rationales guided purchase and testing of 283 molecules. Two related compounds reduced MRSA burden about tenfold in skin and thigh infection models and showed low human-cell toxicity. Candidates remain preclinical.\n\nUpdate (2023-12-04): ARC Evals is now METR December 4, 2023 ARC Evals is wrapping up our incubation period at ARC, and spinning off into our own standalone nonprofit. Read more. 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Read more","excerpt":"ARC Evals is now METR December 4, 2023 ARC Evals is wrapping up our incubation period at ARC, and spinning off into our own standalone nonprofit. 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