{"data":{"event":{"id":"144b9fdd-a57e-4524-844a-efbbb7bdd21b","slug":"chemcrow-gpt4-chemistry-agent","title":"ChemCrow uses GPT-4 plus tools to execute organic-chemistry tasks","short_summary":"EPFL and collaborators published ChemCrow in Nature Machine Intelligence on 8 May 2024, an agent that used GPT-4 and 18 chemistry tools to plan syntheses including an insect repellent and organocatalysts.","full_description":"Expert and LLM evaluations found the tool-using agent more reliable than an unaided LLM on chemistry tasks. Demonstrations included autonomous planning and, in some cases, execution guidance. It is a research prototype, not a replacement for process chemistry.","ledger_type":"benefit","primary_domain_id":"901fb1fb-04f9-453b-a00e-22cbd3fe517c","event_status":"verified","event_date":"2024-05-08T00:00:00.000Z","discovery_date":"2024-05-08T00:00:00.000Z","first_published_date":"2024-05-08T00:00:00.000Z","last_reviewed_date":"2024-05-08T00:00:00.000Z","geographic_scope":"Laboratory research (Switzerland and collaborators)","affected_population":"Computational and synthetic chemists testing agents","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.5500","evidence_multiplier":"0.7000","realization_multiplier":"0.5000","durability_multiplier":"0.4500","current_event_score":"0.155900","confidence_level":"high","score_explanation":"Notable chemistry-agent demonstration (tier 2). Shared credit with tools and humans. Peer-reviewed. Lab-scale realization. Quickly superseded agent stacks.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2024-05-08T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Chemistry","domain_slug":"chemistry","methodology_version":"0.1"},"contributions":[{"id":"7cafab32-5a8e-4e9c-adb7-da918aa1bd4d","event_id":"144b9fdd-a57e-4524-844a-efbbb7bdd21b","model_id":"4bac22cf-53ad-427e-a527-7fd8cb24abb2","role_description":"Reasoning LLM that called ChemCrow tools.","attribution_multiplier":"0.5500","credit_share":"0.6000","contribution_score":"0.155900","attribution_rationale":"GPT-4 was the controller; 18 expert tools and human evaluation were essential.","attribution_confidence":"medium","first_used_date":"2024-05-08T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"gpt-4","model_name":"GPT-4","identity_class":"named_release","is_internal":false,"family_name":"GPT","family_slug":"openai-gpt","organization_name":"OpenAI","organization_slug":"openai"}],"sources":[{"id":"5a18fa15-c4bd-4de1-bbe4-9ef2528920bc","event_id":"144b9fdd-a57e-4524-844a-efbbb7bdd21b","url":"https://www.nature.com/articles/s42256-024-00832-8","canonical_url":"https://www.nature.com/articles/s42256-024-00832-8","source_type":"peer_reviewed","publisher":"Nature Machine Intelligence","author":null,"publication_date":"2024-05-08T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Augmenting large language models with chemistry tools","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"8c00502e-cfff-418b-8105-c62033427d97","event_id":"144b9fdd-a57e-4524-844a-efbbb7bdd21b","claim_text":"ChemCrow planned and in reported cases executed syntheses of small molecules using GPT-4 plus chemistry tools.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"8785ff68-7dba-41bb-b48b-2590d245eebd","event_id":"144b9fdd-a57e-4524-844a-efbbb7bdd21b","model_id":null,"previous_score":"0.000000","new_score":"0.155900","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":3,"durability":0.45,"attribution":0.55,"realization":0.5},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Computer Science","slug":"computer-science"}]},"methodology_version":"0.1"}