{"data":{"event":{"id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","slug":"chai-1-open-complex-prediction","title":"Chai-1 offers an open model for biomolecular complex prediction","short_summary":"Chai Discovery released Chai-1 in September–October 2024 as an open multi-modal structure model reporting PoseBusters and CASP15 scores near AlphaFold 3, with a web server usable for commercial drug discovery.","full_description":"The bioRxiv technical report described single-sequence and MSA modes and optional experimental restraints. Weights were released under a permissive license and a free web interface. Benchmarks are author-reported; there is no Nature/Science paper yet. Independent users have adopted the tool, but head-to-head audits vary by target class.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"provisional","event_date":"2024-10-10T00:00:00.000Z","discovery_date":"2024-10-10T00:00:00.000Z","first_published_date":"2024-10-10T00:00:00.000Z","last_reviewed_date":"2024-10-10T00:00:00.000Z","geographic_scope":"Global structural-biology and industry users","affected_population":"Drug-discovery and academic folding users of the open model","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.9000","evidence_multiplier":"0.3500","realization_multiplier":"0.6000","durability_multiplier":"0.5000","current_event_score":"0.283500","confidence_level":"medium","score_explanation":"Notable open AF3-class tool (tier 2). High attribution. Evidence is a technical report (0.35). Realization includes open weights and commercial web use. Durability medium as Boltz and AF3 successors compete.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2024-10-10T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"771a3a59-d443-46dd-aead-47fcab223aa0","event_id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","model_id":"55a6a4f5-57f6-44f7-9d22-26375e8e1be4","role_description":"Open structure-prediction model and server.","attribution_multiplier":"0.9000","credit_share":"1.0000","contribution_score":"0.283500","attribution_rationale":"The released model is the product.","attribution_confidence":"medium","first_used_date":"2024-09-09T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"chai-1","model_name":"Chai-1","identity_class":"named_release","is_internal":false,"family_name":"Chai","family_slug":"chai-discovery-chai","organization_name":"Chai Discovery","organization_slug":"chai-discovery"}],"sources":[{"id":"ee1b5637-a71f-4208-8082-65911a3608f7","event_id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","url":"https://www.chaidiscovery.com/news/introducing-chai-1","canonical_url":"https://www.chaidiscovery.com/news/introducing-chai-1","source_type":"developer_announcement","publisher":"Chai Discovery","author":null,"publication_date":"2024-09-09T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Introducing Chai-1","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"89aaa362-a9a2-4e48-80e5-f05ec2a701d4","event_id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","url":"https://www.biorxiv.org/content/10.1101/2024.10.10.615955v1","canonical_url":"https://www.biorxiv.org/content/10.1101/2024.10.10.615955v1","source_type":"preprint","publisher":"bioRxiv","author":null,"publication_date":"2024-10-11T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Chai-1: Decoding the molecular interactions of life","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"edb2e431-490c-4cde-853c-c8aa1cd5f284","event_id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","claim_text":"Chai-1 was released with weights and reported AF3-comparable scores on selected public benchmarks.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"58941c60-c0d8-4bfd-9611-ccb2e64c3737","event_id":"2abacfcf-ce35-417f-b422-06a2ab2b3c98","model_id":null,"previous_score":"0.000000","new_score":"0.283500","previous_factors":{},"new_factors":{"evidence":0.35,"base_score":3,"durability":0.5,"attribution":0.9,"realization":0.6},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Medicine & Health","slug":"medicine-health"}]},"methodology_version":"0.1"}