{"data":{"event":{"id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","slug":"bindcraft-oneshot-protein-binders","title":"BindCraft designs nanomolar binders without high-throughput screening","short_summary":"EPFL-led BindCraft, published in Nature on 27 August 2025, used AlphaFold2 weights to design binders with 10–100 percent experimental success across diverse targets, including allergen, Cas9, toxin, and AAV applications.","full_description":"The open pipeline reported one-shot binder design without known sites in some cases and showed functional effects in patient-derived IgE samples, Cas9 modulation, toxin cytotoxicity reduction, and AAV retargeting. It depends on AlphaFold2 as a scoring/design prior, so credit is shared with that model family.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"verified","event_date":"2025-08-27T00:00:00.000Z","discovery_date":"2025-08-27T00:00:00.000Z","first_published_date":"2025-08-27T00:00:00.000Z","last_reviewed_date":"2025-08-27T00:00:00.000Z","geographic_scope":"Global open protein-design community","affected_population":"Labs running BindCraft for binder campaigns","base_impact_tier":3,"base_score":"10.00","attribution_multiplier":"0.5500","evidence_multiplier":"0.7000","realization_multiplier":"0.6000","durability_multiplier":"0.7000","current_event_score":"1.403900","confidence_level":"high","score_explanation":"Major practical binder method (tier 3). Attribution split with AlphaFold2 (0.55). Nature plus open code. Realization includes functional assays beyond binding. Durable pipeline.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2025-08-27T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"edeaa2bd-fde6-432a-9a51-850d26c088f8","event_id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","model_id":"cd8f4833-192c-4ef2-846d-484b134cc1c7","role_description":"Open pipeline that optimized binders using AF2-based losses.","attribution_multiplier":"0.5500","credit_share":"0.5500","contribution_score":"0.889400","attribution_rationale":"Pipeline and experimental campaign are new; AF2 weights are essential.","attribution_confidence":"medium","first_used_date":"2024-09-30T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"bindcraft","model_name":"BindCraft","identity_class":"named_release","is_internal":false,"family_name":"BindCraft","family_slug":"epfl-bindcraft","organization_name":"EPFL","organization_slug":"epfl"},{"id":"3ea36ef0-dc4e-4f68-b7af-113a11cde854","event_id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","model_id":"4dbd477f-e233-4221-a431-4e7a13a1f901","role_description":"Provided weights used as the design/scoring engine.","attribution_multiplier":"0.5000","credit_share":"0.3500","contribution_score":"0.514500","attribution_rationale":"BindCraft explicitly leverages AF2 weights; AF2 was not trained for this campaign.","attribution_confidence":"medium","first_used_date":"2021-07-15T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"alphafold-2","model_name":"AlphaFold 2","identity_class":"named_release","is_internal":false,"family_name":"AlphaFold","family_slug":"google-deepmind-alphafold","organization_name":"Google DeepMind","organization_slug":"google-deepmind"}],"sources":[{"id":"d8b75752-06ba-4d42-815e-9a85103c6640","event_id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","url":"https://www.nature.com/articles/s41586-025-09429-6","canonical_url":"https://www.nature.com/articles/s41586-025-09429-6","source_type":"peer_reviewed","publisher":"Nature","author":null,"publication_date":"2025-08-27T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"One-shot design of functional protein binders with BindCraft","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"04c3226d-e868-42bf-a9b3-f49aded6e0b2","event_id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","claim_text":"BindCraft produced experimentally successful binders across multiple target classes with reported functional follow-ups.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"551eb00b-8785-48cf-b4d5-eaa12d4abda3","event_id":"d1815ee7-651d-42cb-9bda-78f358b33b4a","model_id":null,"previous_score":"0.000000","new_score":"1.403900","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":10,"durability":0.7,"attribution":0.55,"realization":0.6},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Medicine & Health","slug":"medicine-health"}]},"methodology_version":"0.1"}