{"data":{"event":{"id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","slug":"alphaproteo-high-affinity-binders","title":"AlphaProteo designs experimentally validated high-affinity protein binders","short_summary":"DeepMind’s AlphaProteo, released 5 September 2024, produced binders to seven targets with higher experimental success and affinities than prior computational methods; Crick Institute labs confirmed SARS-CoV-2 and VEGF-A functions.","full_description":"A technical report described generative design plus filtering. Success rates reached 88 percent on BHRF1 in DeepMind’s wet lab. TNFα failed. Some SC2RBD binders blocked viral infection in collaborator assays. No therapeutic development is claimed.","ledger_type":"benefit","primary_domain_id":"8f1af1b9-7302-4b51-aae9-fdfac04d158a","event_status":"verified","event_date":"2024-09-05T00:00:00.000Z","discovery_date":"2024-09-05T00:00:00.000Z","first_published_date":"2024-09-05T00:00:00.000Z","last_reviewed_date":"2024-09-05T00:00:00.000Z","geographic_scope":"UK wet-lab and collaborator labs","affected_population":"Protein-binder researchers","base_impact_tier":3,"base_score":"10.00","attribution_multiplier":"0.8000","evidence_multiplier":"0.5000","realization_multiplier":"0.5500","durability_multiplier":"0.6500","current_event_score":"1.215500","confidence_level":"high","score_explanation":"Strong experimental binder campaign (tier 3). High attribution with human screening. Technical report plus independent collaborator assays (0.50). Realization is research binders. Durable sequences.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2024-09-05T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Biology","domain_slug":"biology","methodology_version":"0.1"},"contributions":[{"id":"13cec7d3-9360-4bcc-a65a-facb1050baa9","event_id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","model_id":"4cffba22-24ff-4f78-a17f-f5e091077c0e","role_description":"Designed binder sequences later expressed and assayed.","attribution_multiplier":"0.8000","credit_share":"0.8500","contribution_score":"1.215500","attribution_rationale":"Model generated candidates; wet lab filtered successes.","attribution_confidence":"medium","first_used_date":"2024-09-05T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"alphaproteo","model_name":"AlphaProteo","identity_class":"named_release","is_internal":false,"family_name":"AlphaProteo","family_slug":"google-deepmind-alphaproteo","organization_name":"Google DeepMind","organization_slug":"google-deepmind"}],"sources":[{"id":"6cee3356-a589-491f-af38-106a85cd07e1","event_id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","url":"https://deepmind.google/discover/blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/","canonical_url":"https://deepmind.google/discover/blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/","source_type":"developer_announcement","publisher":"Google DeepMind","author":null,"publication_date":"2024-09-05T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"AlphaProteo generates novel proteins for biology and health research","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"03965573-0727-42a9-87f5-1d728e6daa49","event_id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","url":"https://arxiv.org/abs/2409.08022","canonical_url":"https://arxiv.org/abs/2409.08022","source_type":"preprint","publisher":"arXiv","author":null,"publication_date":"2024-09-13T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"De novo design of high-affinity protein binders with AlphaProteo","excerpt":null,"content_hash":null,"source_reliability_class":"low","is_primary_source":true,"is_independent":false,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"3c49f95b-dc4f-41c2-a590-3ac0f019d07b","event_id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","claim_text":"AlphaProteo binders to seven targets were experimentally confirmed, with collaborator validation on SC2RBD and VEGF-A.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"ec1e2fcb-cb02-4a41-ba00-4040e96b4d9c","event_id":"446dbca2-003e-4675-ad77-a26d6ce0f21d","model_id":null,"previous_score":"0.000000","new_score":"1.215500","previous_factors":{},"new_factors":{"evidence":0.5,"base_score":10,"durability":0.65,"attribution":0.8,"realization":0.55},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Medicine & Health","slug":"medicine-health"}]},"methodology_version":"0.1"}