{"data":{"event":{"id":"c20042d4-e0bb-42f0-9b1e-ae3ec87e2331","slug":"alphamissense-proteome-pathogenicity","title":"AlphaMissense classifies most possible human missense variants","short_summary":"DeepMind released AlphaMissense and a catalog covering about 71 million human missense variants, classifying 89 percent as likely benign or likely pathogenic, in Science on 19 September 2023.","full_description":"AlphaMissense adapts AlphaFold-style modeling and is fine-tuned on population-frequency labels rather than ClinVar. The authors reported strong benchmark performance without training on those clinical labels and released proteome-wide scores. The resource is explicitly not approved for clinical diagnosis. 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