{"data":{"event":{"id":"86577a60-0420-48c5-96b5-2ab730a0f846","slug":"abaucin-acinetobacter-antibiotic","title":"Deep learning identifies abaucin, a narrow-spectrum Acinetobacter antibiotic","short_summary":"MIT and McMaster researchers trained a neural net on in-vitro growth data and identified abaucin, which killed A. baumannii in culture and a mouse wound model, published 25 May 2023.","full_description":"After screening about 7,500 molecules, the team trained a message-passing model and searched for new actives. Abaucin (related to RS102895) showed narrow-spectrum activity and a mechanism involving lipoprotein trafficking (LolE). It is a preclinical lead, not a human drug. Human chemists and microbiologists designed assays and follow-up.","ledger_type":"benefit","primary_domain_id":"c09546b6-10f8-48df-8347-0c1979416464","event_status":"verified","event_date":"2023-05-25T00:00:00.000Z","discovery_date":"2023-05-25T00:00:00.000Z","first_published_date":"2023-05-25T00:00:00.000Z","last_reviewed_date":"2023-05-25T00:00:00.000Z","geographic_scope":"Laboratory and mouse studies (Canada/USA)","affected_population":"Preclinical antimicrobial researchers","base_impact_tier":2,"base_score":"3.00","attribution_multiplier":"0.4000","evidence_multiplier":"0.7000","realization_multiplier":"0.4500","durability_multiplier":"0.5000","current_event_score":"0.075600","confidence_level":"high","score_explanation":"Notable AI-assisted lead (tier 2), not a new approved antibiotic. Modest attribution (model ranked compounds; humans screened and validated). Peer review plus mouse data. Realization is preclinical. Durability uncertain without development.","methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","original_methodology_version_id":"d7881163-fb23-4e71-8625-bac1a8662c0f","published_at":"2023-05-25T00:00:00.000Z","created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z","flags":[],"domain_name":"Medicine & Health","domain_slug":"medicine-health","methodology_version":"0.1"},"contributions":[{"id":"fb4b6414-a349-4b9a-a1a4-82ab107d0849","event_id":"86577a60-0420-48c5-96b5-2ab730a0f846","model_id":"b4756942-522a-462d-b689-ca8a710aea46","role_description":"Predicted A. baumannii growth inhibition to prioritize compounds.","attribution_multiplier":"0.4000","credit_share":"0.4000","contribution_score":"0.075600","attribution_rationale":"Model prioritized candidates from a library; discovery still depended on wet-lab screening and mechanism work.","attribution_confidence":"medium","first_used_date":"2023-05-25T00:00:00.000Z","model_version_if_known":null,"review_status":"approved","created_at":"2026-09-13T20:47:20.075Z","model_slug":"chemprop-style-internal-research-model","model_name":"Chemprop-style Internal Research Model","identity_class":"internal_unreleased","is_internal":true,"family_name":"Chemprop","family_slug":"mit-chemprop","organization_name":"Massachusetts Institute of Technology","organization_slug":"mit"}],"sources":[{"id":"b1166ea7-86e0-4e94-bfc7-227d1972dbf8","event_id":"86577a60-0420-48c5-96b5-2ab730a0f846","url":"https://www.nature.com/articles/s41589-023-01349-8","canonical_url":"https://www.nature.com/articles/s41589-023-01349-8","source_type":"peer_reviewed","publisher":"Nature Chemical Biology","author":null,"publication_date":"2023-05-25T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii","excerpt":null,"content_hash":null,"source_reliability_class":"high","is_primary_source":true,"is_independent":true,"is_peer_reviewed":true,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"},{"id":"81d28f77-265d-46b2-a584-40564b9f451c","event_id":"86577a60-0420-48c5-96b5-2ab730a0f846","url":"https://news.mit.edu/2023/using-ai-scientists-combat-drug-resistant-infections-0525","canonical_url":"https://news.mit.edu/2023/using-ai-scientists-combat-drug-resistant-infections-0525","source_type":"university_announcement","publisher":"MIT News","author":null,"publication_date":"2023-05-25T00:00:00.000Z","retrieved_at":"2026-09-13T20:47:20.075Z","title":"Using AI, scientists find a drug that could combat drug-resistant infections","excerpt":null,"content_hash":null,"source_reliability_class":"medium","is_primary_source":true,"is_independent":true,"is_peer_reviewed":false,"archived_url":null,"created_at":"2026-09-13T20:47:20.075Z"}],"claims":[{"id":"b7fedf5f-a31d-4f06-8c44-7eb2c3715442","event_id":"86577a60-0420-48c5-96b5-2ab730a0f846","claim_text":"A machine-learning screen identified abaucin as a narrow-spectrum A. baumannii active with mouse wound efficacy.","claim_type":"outcome","claim_status":"supported","confidence_score":null,"created_at":"2026-09-13T20:47:20.075Z","updated_at":"2026-09-13T20:47:20.075Z"}],"revisions":[{"id":"4bfec0ee-ad40-411b-894d-ed07ef31a076","event_id":"86577a60-0420-48c5-96b5-2ab730a0f846","model_id":null,"previous_score":"0.000000","new_score":"0.075600","previous_factors":{},"new_factors":{"evidence":0.7,"base_score":3,"durability":0.5,"attribution":0.4,"realization":0.45},"change_reason":"Initial adjudicated seed score under methodology 0.1.","trigger_type":"seed","trigger_source_ids":null,"reviewer_id":null,"review_status":"published","created_at":"2026-09-13T20:47:20.075Z"}],"secondary":[{"name":"Biology","slug":"biology"},{"name":"Chemistry","slug":"chemistry"}]},"methodology_version":"0.1"}